The sweet and sour of cancer: glycans as novel therapeutic targets.
作者： Mark M. Fuster , Jeffrey D. Esko
DOI: 10.1038/NRC1649
关键词:
摘要: A growing body of evidence supports crucial roles for glycans at various pathophysiological steps tumour progression. Glycans regulate proliferation, invasion, haematogenous metastasis and angiogenesis, increased understanding these sets the stage developing pharmaceutical agents that target molecules. Such novel might be used alone or in combination with operative and/or chemoradiation strategies treating cancer.
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scilit.net参考文章(156)
Teh-Ying Chou, Gerald W. Hart, O-Linked N-Acetylglucosamine and Cancer: Messages from the Glycosylation of C-Myc Advances in Experimental Medicine and Biology. ,vol. 491, pp. 413- 418 ,(2001) , 10.1007/978-1-4615-1267-7_26
Chi-Huey Wong, Carbohydrate-based drug discovery. Carbohydrate-based drug discovery.. pp. 945- ,(2003)
Sylvain Julien, Marie-Ange Krzewinski-Recchi, Anne Harduin-Lepers, Valérie Gouyer, Guillemette Huet, Xuefen Le Bourhis, Philippe Delannoy, Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA. Glycoconjugate Journal. ,vol. 18, pp. 883- 893 ,(2001) , 10.1023/A:1022200525695
T.A. Fritz, F.N. Lugemwa, A.K. Sarkar, J.D. Esko, Biosynthesis of heparan sulfate on beta-D-xylosides depends on aglycone structure. Journal of Biological Chemistry. ,vol. 269, pp. 300- 307 ,(1994) , 10.1016/S0021-9258(17)42349-0
Israel Vlodavsky, Yael Friedmann, Michael Elkin, Helena Aingorn, Ruth Atzmon, Rivka Ishai-Michaeli, Menachem Bitan, Orit Pappo, Tuvia Peretz, Israel Michal, Larissa Spector, Iris Pecker, Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis. Nature Medicine. ,vol. 5, pp. 793- 802 ,(1999) , 10.1038/10518
Peter M. Howley, Mark A. Israel, Joe W. Gray, Craig B. Thompson, John Mendelsohn, The Molecular Basis of Cancer ,(1985)
Maria Granovsky, Jimmie Fata, Judy Pawling, William J. Muller, Rama Khokha, James W. Dennis, Suppression of tumor growth and metastasis in Mgat5-deficient mice. Nature Medicine. ,vol. 6, pp. 306- 312 ,(2000) , 10.1038/73163
A.B. Al-Mehdi, K. Tozawa, A.B. Fisher, L. Shientag, A. Lee, R.J. Muschel, Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis. Nature Medicine. ,vol. 6, pp. 100- 102 ,(2000) , 10.1038/71429
N. Kojima, S. Hakomori, Cell adhesion, spreading, and motility of GM3-expressing cells based on glycolipid-glycolipid interaction. Journal of Biological Chemistry. ,vol. 266, pp. 17552- 17558 ,(1991) , 10.1016/S0021-9258(19)47407-3
Thomas Boehm, Judah Folkman, Timothy Browder, Michael S. O'Reilly, Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance Nature. ,vol. 390, pp. 404- 407 ,(1997) , 10.1038/37126