Tight glycemic control reduces heart inflammation and remodeling during acute myocardial infarction in hyperglycemic patients.
作者： Raffaele Marfella , Clara Di Filippo , Michele Portoghese , Franca Ferraraccio , Maria Rosaria Rizzo
DOI: 10.1016/J.JACC.2009.01.041
关键词:
摘要: Objectives We analyzed the molecular mechanisms evoked by tight glycemic control during post-infarction remodeling in human hearts. Background The which improves heart acute myocardial infarction (AMI) are still largely unknown. Methods Eighty-eight patients with first AMI undergoing coronary bypass surgery were studied: 38 normoglycemic served as group; hyperglycemic (glucose ≥140 mg/dl) randomized to intensive (IGC) (n = 25; glucose 80 140 or conventional (CGC) 180 200 for almost 3 days before surgery, insulin infusion followed subcutaneous treatment. Echocardiographic parameters investigated at admission and after treatment period. During oxidative stress (nitrotyrosine, superoxide anion [O2–] production, inducible nitric oxide synthase [iNOS]), inflammation (nuclear factor kappa B [NFκB], tumor necrosis [TNF]-α, apoptosis (caspase-3) biopsy specimens taken from peri-infarcted area. Results Compared patients, had higher performance index (MPI) (p Conclusions Tight control, reducing inflammation, might reduce areas patients.
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Raffaele Marfella, Michele D’Amico, Clara Di Filippo, Alfonso Baldi, Mario Siniscalchi, Ferndinando Carlo Sasso, Michele Portoghese, Ornella Carbonara, Basilio Crescenzi, Paolo Sangiuolo, Giovanni Francesco Nicoletti, Raffaele Rossiello, Franca Ferraraccio, Federico Cacciapuoti, Mario Verza, Ludovico Coppola, Francesco Rossi, Giuseppe Paolisso, Increased activity of the ubiquitin-proteasome system in patients with symptomatic carotid disease is associated with enhanced inflammation and may destabilize the atherosclerotic plaque: effects of rosiglitazone treatment. Journal of the American College of Cardiology. ,vol. 47, pp. 2444- 2455 ,(2006) , 10.1016/J.JACC.2006.01.073
Andrew Bowie, Luke A.J O’Neill, Oxidative stress and nuclear factor-κB activation: A reassessment of the evidence in the light of recent discoveries Biochemical Pharmacology. ,vol. 59, pp. 13- 23 ,(2000) , 10.1016/S0006-2952(99)00296-8
J. S. Beckman, W. H. Koppenol, Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. American Journal of Physiology-cell Physiology. ,vol. 271, ,(1996) , 10.1152/AJPCELL.1996.271.5.C1424
Elliott Antman, Jean-Pierre Bassand, Werner Klein, Magnus Ohman, Jose Luis Lopez Sendon, Lars Rydén, Maarten Simoons, Michal Tendera, Myocardial infarction redefined--a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. Journal of the American College of Cardiology. ,vol. 36, pp. 959- 969 ,(2000) , 10.1016/S0735-1097(00)00804-4
Hang-Xiang Zhang, Yi-Min Zang, Jian-Hua Huo, Shao-Jun Liang, Hai-Feng Zhang, Yue-Min Wang, Qian Fan, Wen-Yi Guo, Hai-Chang Wang, Feng Gao, Physiologically Tolerable Insulin Reduces Myocardial Injury and Improves Cardiac Functional Recovery in Myocardial Ischemic/Reperfused Dogs Journal of Cardiovascular Pharmacology. ,vol. 48, pp. 306- 313 ,(2006) , 10.1097/01.FJC.0000249873.73197.C3
Greet Van den Berghe, Pieter Wouters, Frank Weekers, Charles Verwaest, Frans Bruyninckx, Miet Schetz, Dirk Vlasselaers, Patrick Ferdinande, Peter Lauwers, Roger Bouillon, Intensive Insulin Therapy in Critically Ill Patients The New England Journal of Medicine. ,vol. 345, pp. 1359- 1367 ,(2001) , 10.1056/NEJMOA011300
Margaret A. Arstall, Douglas B. Sawyer, Ryuji Fukazawa, Ralph A. Kelly, Cytokine-Mediated Apoptosis in Cardiac Myocytes: The Role of Inducible Nitric Oxide Synthase Induction and Peroxynitrite Generation Circulation Research. ,vol. 85, pp. 829- 840 ,(1999) , 10.1161/01.RES.85.9.829
Rafael Díaz, Abhinav Goyal, Shamir R Mehta, Rizwan Afzal, Denis Xavier, Prem Pais, Susan Chrolavicius, Jun Zhu, Khawar Kazmi, Lisheng Liu, Andrzej Budaj, Mohammad Zubaid, Alvaro Avezum, Mikhail Ruda, Salim Yusuf, None, Glucose-insulin-potassium therapy in patients with ST-segment elevation myocardial infarction. JAMA. ,vol. 298, pp. 2399- 2405 ,(2007) , 10.1001/JAMA.298.20.2399
Karol A Kaminski, Tomasz A Bonda, Janusz Korecki, Wlodzimierz J Musial, Oxidative stress and neutrophil activation--the two keystones of ischemia/reperfusion injury. International Journal of Cardiology. ,vol. 86, pp. 41- 59 ,(2002) , 10.1016/S0167-5273(02)00189-4
M Thoenes, EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE IN FAILING AND NON-FAILING HUMAN HEART Journal of Molecular and Cellular Cardiology. ,vol. 28, pp. 165- 169 ,(1996) , 10.1006/JMCC.1996.0016