Microsomal electron transport reactions. 3. Cooperative interactions between reduced diphosphopyridine nucleotide and reduced triphosphopyridine nucleotide linked reactions.
作者： Beverly S. Cohen , Ronald W. Estabrook
DOI: 10.1016/0003-9861(71)90185-8
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摘要: Abstract DPNH, when added in the presence of a TPNH-generating system with steadystate concentrations TPNH as low 1 μ m , significantly affects rate formaldehyde formation during rabbit liver microsome catalyzed oxidative demethylation aminopyrine. Further, steady-state can cause substantial increase (up to fourfold) DPNH oxidation by microsomes. The unexpected ability markedly stimulate aminopyrine metabolism either or TPN + plus is not explained any existing schemes microsomal electron transport. same true for levels oxidation. present paper suggests two possible mechanisms transport account cooperative interaction between and DPNH. These findings are considered physiological significance since normal cytosol environment hepatic cell contains both
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