Inorganic–organic hybrid alginate beads with LCST near human body temperature for sustained dual‐sensitive drug delivery
作者： Jun Shi , Lihua Liu , Xiaopei Liu , Ximeng Sun , Shaokui Cao
DOI: 10.1002/PAT.1149
关键词:
摘要: In order to obtain dual-stimuli-responsive (temperature/pH) alginate beads that exhibit LCST close human body temperature for sustained drug release applications, poly (NIPAAm-co-AAm) hydrogel (with 37.5°C) were selected and associated with calcium prepare inorganic–organic hybrid biomineralized polysaccharide via a one-step method in this paper. Scanning electron microscopy (SEM) energy dispersive X-ray spectrometer (EDS) results demonstrated phosphate could not only be found the surface but also cross-section of beads. Both equilibrium swelling indomethacin behavior pH- thermo-responsive. addition, profile membrane: amount reached 96% within 4 hr unmineralized beads, while 64% obtained after subjecting same treatment. These indicate membrane prevent permeability encapsulated reduce rate effectively. The studied system has potential used as an effective smart sustainable delivery biomedical applications. Copyright © 2008 John Wiley & Sons, Ltd.
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