Migrational changes of mesenchymal stem cells in response to cytokines, growth factors, hypoxia, and aging.
作者： Yahaira Naaldijk , Adiv A. Johnson , Stefan Ishak , Hans Jörg Meisel , Christian Hohaus
DOI: 10.1016/J.YEXCR.2015.08.019
关键词:
摘要: Mesenchymal stem cells (MSCs) are non-immunogenic, multipotent with at least trilineage differentiation potential. They promote wound healing, improve regeneration of injured tissue, and mediate numerous other health effects. MSCs migrate to sites injury stimulate repair either through direct or indirectly the stimulation endogenous mechanisms. Using in vitro scratch assay, we show that inflammatory cytokines, chemokines, growth factors TNF-α, SDF-1, PDGF, bFGF enhance migration rat under normoxic conditions, while IFN-γ, MSC hypoxic conditions. This indicates oxygen concentration affects how will response specific and, consistent this, differential expression cytokines was observed versus transwell find bFGF, IGF-1, SDF-1 significantly increase transmigration compared unstimulated medium. derived from aged rats exhibited comparable young even after application factors. Similarly, aged, human donors did not statistically differ umbilical cord tissue younger donors.
core.ac.uk
lboro.ac.uk
elsevier.com
sci-hub.se 参考文章(57)
Jamie R. Schoenborn, Christopher B. Wilson, Regulation of interferon-gamma during innate and adaptive immune responses. Advances in Immunology. ,vol. 96, pp. 41- 101 ,(2007) , 10.1016/S0065-2776(07)96002-2
A F Panasuk, S F Rudakowa, U F Deriglasova, I A Ruadkow, A J Friedenstein, N N Kulagina, E A Luriá, Precursors for fibroblasts in different populations of hematopoietic cells as detected by the in vitro colony assay method. Experimental Hematology. ,vol. 2, pp. 83- 92 ,(1974)
Louise E. Glover, Karina Irizarry, Melanie Scully, Eric L. Campbell, Brittelle E. Bowers, Carol M. Aherne, Douglas J. Kominsky, Christopher F. MacManus, Sean P. Colgan, IFN-γ Attenuates Hypoxia-Inducible Factor (HIF) Activity in Intestinal Epithelial Cells through Transcriptional Repression of HIF-1β Journal of Immunology. ,vol. 186, pp. 1790- 1798 ,(2011) , 10.4049/JIMMUNOL.1001442
Mikako Sasaki, Riichiro Abe, Yasuyuki Fujita, Satomi Ando, Daisuke Inokuma, Hiroshi Shimizu, Mesenchymal Stem Cells Are Recruited into Wounded Skin and Contribute to Wound Repair by Transdifferentiation into Multiple Skin Cell Type Journal of Immunology. ,vol. 180, pp. 2581- 2587 ,(2008) , 10.4049/JIMMUNOL.180.4.2581
Ye Wang, Yubin Deng, Guang-Qian Zhou, SDF-1α/CXCR4-mediated migration of systemically transplanted bone marrow stromal cells towards ischemic brain lesion in a rat model Brain Research. ,vol. 1195, pp. 104- 112 ,(2008) , 10.1016/J.BRAINRES.2007.11.068
Thomas P. Lozito, Rocky S. Tuan, Mesenchymal stem cells inhibit both endogenous and exogenous MMPs via secreted TIMPs Journal of Cellular Physiology. ,vol. 226, pp. 385- 396 ,(2011) , 10.1002/JCP.22344
Yu-li Huang, Ruo-feng Qiu, Wei-yi Mai, Jian Kuang, Xiao-yan Cai, Yu-gang Dong, Yun-zhao Hu, Yuan-bin Song, An-ping Cai, Zhi-gao Jiang, Effects of insulin-like growth factor-1 on the properties of mesenchymal stem cells in vitro Journal of Zhejiang University SCIENCE B. ,vol. 13, pp. 20- 28 ,(2012) , 10.1631/JZUS.B1100117
Yuxiang Liu, Shanna R. Cox, Toshisuke Morita, Stella Kourembanas, Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells Identification of a 5′ Enhancer Circulation Research. ,vol. 77, pp. 638- 643 ,(1995) , 10.1161/01.RES.77.3.638
Borhane Annabi, Ying-Ta Lee, Sandra Turcotte, Emmanuelle Naud, Richard R. Desrosiers, Martin Champagne, Nicoletta Eliopoulos, Jacques Galipeau, Richard Béliveau, Hypoxia promotes murine bone-marrow-derived stromal cell migration and tube formation. Stem Cells. ,vol. 21, pp. 337- 347 ,(2003) , 10.1634/STEMCELLS.21-3-337
Marijke W. Maijenburg, C. Ellen van der Schoot, Carlijn Voermans, Mesenchymal Stromal Cell Migration: Possibilities to Improve Cellular Therapy Stem Cells and Development. ,vol. 21, pp. 19- 29 ,(2012) , 10.1089/SCD.2011.0270