Human DNA Topoisomerase I: Structure, Enzymology and Biology
作者： James J. Champoux
DOI: 10.1007/978-1-4614-0323-4_2
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摘要: Human topoisomerase I (Top1) catalyzes the reversible cleavage of one strand DNA to provide swivels relax supercoils associated with replication, transcription, and chromatin assembly. The reaction occurs covalent attachment an active-site tyrosine 3′ end broken strand; religation restores continuity releases enzyme. During cleaved state, relaxation torsionally strained by a controlled rotation mechanism. X-ray crystal structures enzyme bound combined single-molecule experiments insights into chemistry, specificity, dynamics process. A failure Top1 carry out at lesions or in presence drugs such as camptothecin causes damage that must be repaired if cell is survive. list proteins known interact suggests has functions vivo extend well beyond previously characterized roles
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