Pathogen-Associated Molecular Patterns Induced Crosstalk between Dendritic Cells, T Helper Cells, and Natural Killer Helper Cells Can Improve Dendritic Cell Vaccination
作者： Tammy Oth , Joris Vanderlocht , Catharina H. M. J. Van Elssen , Gerard M. J. Bos , Wilfred T. V. Germeraad
DOI: 10.1155/2016/5740373
关键词:
摘要: A coordinated cellular interplay is of crucial importance in both host defense against pathogens and malignantly transformed cells. The various interactions Dendritic Cells (DC), Natural Killer (NK) cells, T helper (Th) cells can be influenced by a variety pathogen-associated molecular patterns (PAMPs) will lead to enhanced CD8+ effector cell responses. Specific Pattern Recognition Receptor (PRR) triggering during maturation enables DC enhance Th1 as well NK This effect correlated with the amount IL-12p70 released DC. Activated are able amplify proinflammatory cytokine profile via release IFN-γ. knowledge on how PAMP recognition modulate for design definition appropriate therapeutic cancer vaccines. In this review we discuss potential role specific PAMP-matured optimizing DC-based vaccines, some these efficiently activating Th1, cytotoxic Moreover, optimize also inhibitory effects tumor-derived suppressive factors, example, NK-DC crosstalk, should taken into account. Finally, tumor microenvironment vaccination efficacy proposals overcome using combination therapies described.
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