Poly(amidoamine) dendrimers as ophthalmic vehicles for ocular delivery of pilocarpine nitrate and tropicamide
作者： Th.F. Vandamme , L. Brobeck
DOI: 10.1016/J.JCONREL.2004.09.015
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摘要: Abstract The purpose of this study was to determine the influence a controlled incremental increase in size, molecular weight and number amine, carboxylate hydroxyl surface groups several series poly(amidoamine) (PAMAM) dendrimers for ocular drug delivery. duration residence time evaluated after solubilization PAMAM (generations 1.5 2–3.5 4) buffered phosphate solutions containing 2‰ (w/v) fluorescein. New Zealand albino rabbit used as an vivo model qualitative quantitative assessment tolerance retention single application 25 μl dendrimer solution eye. same also prolonged miotic or mydriatic activities solutions, some pilocarpine nitrate tropicamide, respectively. Residence longer with carboxylic groups. No prolongation remanence observed when concentration (0.25–2%) increased. on cornea showed size dependency. This allowed novel macromolecular carriers be designed ophthalmic route.
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