Validation of Geant4 for silicon microdosimetry in heavy ion therapy.
作者： D Bolst , S Guatelli , L T Tran , L Chartier , J Davis
关键词:
摘要: Microdosimetry is a particularly powerful method to estimate the relative biological effectiveness (RBE) of any mixed radiation field. This convenient for therapeutic heavy ion therapy (HIT) beams, referring ions larger than protons, where RBE beam can vary significantly along Bragg curve. Additionally, due sharp dose gradients at end peak (BP), or spread out BP, make accurate measurements and estimations properties high spatial resolution required, less millimetre. requirement makes silicon microdosimetry attractive thicknesses sensitive volumes commonly being ∼10 [Formula: see text]m less. Monte Carlo (MC) codes are widely used study complex HIT field as well model response novel microdosimeter detectors when irradiated with beams. Therefore it essential validate MC against experimental measurements. work compares performed in mono-energetic text], text] beams energies, simulation results calculated Geant4 toolkit. Experimental were compared terms microdosimetric spectra (dose lineal energy, text]), mean y D RBE10, estimated by kinetic (MKM). Overall showed reasonable agreement Before distal edge experiment agreed within ∼10% and ∼2% RBE10. Downstream BP was observed between experiment, Simulation downstream had lower values RBE10 higher contribution from lighter fragments heavier fragments.
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