A polyphenol-rich sorghum cereal alters colon microbiota and plasma metabolites in overweight subjects (270.7)

摘要: Diet has the potential to impact gut microbiota and metabolism, with implications for obesity inflammation. We have shown that polyphenol-rich sumac sorghum (contains condensed tannins) alters microbial populations metabolites in rats. The goal of this study was determine if similar effects occur overweight subjects predisposed metabolic syndrome (MS). Subjects (n=24) were randomized a crossover design high (100 g/d) low (50 intakes (4 wk) cereal incorporated their normal diets. Sumac induced compositional changes fecal microbiota, such as an increase (q=0.076) anti-inflammatory Faecalibacterium prausnitzii species. Untargeted metabolomic analysis plasma revealed reductions amino acid (AA) well increases microbially-derived aromatic AA polyphenol metabolites. 3-hydroxyhippurate, product chlorogenic metabolism be reduced individuals impaired glucose tolerance, increased (q=0...