The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: A systems biology approach
作者： Dulce Calçada , Dario Vianello , Enrico Giampieri , Claudia Sala , Gastone Castellani
DOI: 10.1016/J.MAD.2014.01.004
关键词:
摘要: Aging is a biological process characterized by the progressive functional decline of many interrelated physiological systems. In particular, aging associated with development systemic state low-grade chronic inflammation (inflammaging), and deterioration metabolic function. Systems biology has helped in identifying mediators pathways involved these phenomena, mainly through application high-throughput screening methods, valued for their molecular comprehensiveness. Nevertheless, regulation are dynamical processes whose behavior must be understood at multiple levels organization (molecular, cellular, organ, system levels) on time scales. Mathematical modeling such behavior, incorporation mechanistic knowledge interactions between inflammatory mediators, may help devising nutritional interventions capable preventing, or ameliorating, age-associated corresponding © 2014 The Authors.
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Jeremy D. Scheff, Panteleimon D. Mavroudis, Panagiota T. Foteinou, Gary An, Steve E. Calvano, John Doyle, Thomas E. Dick, Stephen F. Lowry, Yoram Vodovotz, Ioannis P. Androulakis, A multiscale modeling approach to inflammation: A case study in human endotoxemia Journal of Computational Physics. ,vol. 244, pp. 279- 289 ,(2013) , 10.1016/J.JCP.2012.09.024
Wanding Zhou, Luay Nakhleh, Properties of metabolic graphs: biological organization or representation artifacts? BMC Bioinformatics. ,vol. 12, pp. 132- 132 ,(2011) , 10.1186/1471-2105-12-132
Ian Jeffery, Paul O'Toole, Diet-microbiota interactions and their implications for healthy living. Nutrients. ,vol. 5, pp. 234- 252 ,(2013) , 10.3390/NU5010234
Karin Breuer, Amir K Foroushani, Matthew R Laird, Carol Chen, Anastasia Sribnaia, Raymond Lo, Geoffrey L Winsor, Robert EW Hancock, Fiona SL Brinkman, David J Lynn, None, InnateDB: systems biology of innate immunity and beyond—recent updates and continuing curation Nucleic Acids Research. ,vol. 41, pp. 1228- 1233 ,(2013) , 10.1093/NAR/GKS1147
A Lewis, DS Wishart, AC Guo, B Gautam, D Tzur, CA Sobsey, R Shaykhutdinov, R Fradette, A De Souza, JA Cruz, Y Xiong, S Bouatra, R Mandal, N Psychogios, I Sinelnikov, HJ Vogel, L Fang, J Peng, J Xia, L Li, C Knox, S Shrivastava, M Clements, E Lim, R Eisner, D Cheng, M Dawe, A Zuniga, N Young, L Jia, R Grenier, DD Hau, P Huang, A Nazyrova, P Liu, I Forsythe, E Dong, D Clive, None, HMDB: a knowledgebase for the human metabolome Nucleic Acids Research. ,vol. 37, pp. 603- 610 ,(2009) , 10.1093/NAR/GKN810
Jennifer L. Gardy, David J. Lynn, Fiona S.L. Brinkman, Robert E.W. Hancock, Enabling a systems biology approach to immunology: focus on innate immunity. Trends in Immunology. ,vol. 30, pp. 249- 262 ,(2009) , 10.1016/J.IT.2009.03.009
D. Szklarczyk, A. Franceschini, M. Kuhn, M. Simonovic, A. Roth, P. Minguez, T. Doerks, M. Stark, J. Muller, P. Bork, L. J. Jensen, C. v. Mering, The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored Nucleic Acids Research. ,vol. 39, pp. 561- 568 ,(2011) , 10.1093/NAR/GKQ973
Karen van Eunen, José A. L. Kiewiet, Hans V. Westerhoff, Barbara M. Bakker, Testing Biochemistry Revisited: How In Vivo Metabolism Can Be Understood from In Vitro Enzyme Kinetics PLoS Computational Biology. ,vol. 8, pp. e1002483- ,(2012) , 10.1371/JOURNAL.PCBI.1002483
Yan Fu, Trevor Glaros, Meng Zhu, Ping Wang, Zhanghan Wu, John J. Tyson, Liwu Li, Jianhua Xing, Network Topologies and Dynamics Leading to Endotoxin Tolerance and Priming in Innate Immune Cells PLoS Computational Biology. ,vol. 8, pp. e1002526- ,(2012) , 10.1371/JOURNAL.PCBI.1002526
Linette Pellis, Marjan J. van Erk, Ben van Ommen, Gertruud C. M. Bakker, Henk F. J. Hendriks, Nicole H. P. Cnubben, Robert Kleemann, Eugene P. van Someren, Ivana Bobeldijk, Carina M. Rubingh, Suzan Wopereis, Plasma metabolomics and proteomics profiling after a postprandial challenge reveal subtle diet effects on human metabolic status Metabolomics. ,vol. 8, pp. 347- 359 ,(2012) , 10.1007/S11306-011-0320-5