Effect of RvD1/FPR2 on inflammatory response in chorioamnionitis.

摘要: Chorioamnionitis (CAM), as a common intrauterine infectious disease, is the leading cause of premature birth, stillbirth, neonatal infection and sepsis. The formyl peptide receptor 2 (FPR2) member GPCRs widely distributed in variety tissues associated with many inflammatory diseases. With discovery FPR2 human placenta, possibility exploring function obstetrics evolving. Resolvin D1 (RvD1) plays an important role resolution inflammation by combining FPR2. In this study, we evaluated RvD1 CAM, not only placenta but also mouse models. expression increased CAM patients downstream PPARγ/NF-κB signalling changed accordingly. Moreover, Fpr2-/- mice were highly susceptible to LPS, displaying worse symptom, compared WT mice. By establishing model trophoblast vitro, it was confirmed that rescued effect LPS on its pathway. Otherwise, improved preterm labour induced LPS. Altogether, these findings show alleviated vivo vitro through FPR2/PPARγ/NF-κB pathway, suggesting RvD1/FPR2 might be novel therapeutic strategy alleviate CAM.