Cytotoxic and antioxidant dihydrobenzofuran neolignans from the seeds of Crataegus pinnatifida.
作者： Xiao-Xiao Huang , Chen-Chen Zhou , Ling-Zhi Li , Ying Peng , Li-Li Lou
DOI: 10.1016/J.FITOTE.2013.09.011
关键词:
摘要: Eight new dihydrobenzofuran neolignans, pinnatifidanin C I-VIII (1-8), together with two known analogs (9-10) were isolated from the seeds of Crataegus pinnatifida. Their structures elucidated by spectroscopic analyses, especially 1D, 2D NMR and CD spectra. The cytotoxic activities all isolates against human cancer cell lines assayed, most interestingly, compound 10 revealed preferred cytotoxicity on HT-1080 line displayed much stronger inhibitory activity (IC50=8.86 μM) compared positive control 5-fluorouracil (IC50=35.62 μM). Meanwhile, antioxidant evaluated using 2,2-diphenyl-1-pikrylhydrazyl (DPPH) 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays, results showed that exhibited potent activity.
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