Antiproliferative effects of bacillus Calmette-Guérin and interferon α2b on human bladder cancer cells in vitro
作者： Kimberley Pryor , Phillip Stricker , Pamela Russell , David Golovsky , Ronald Penny
DOI: 10.1007/BF01517219
关键词:
摘要: Direct inhibitory effects of bacillus Calmette-Guerin (BCG) and interferon α2b (IFNα2b) on six human bladder carcinoma cell lines, UCRU-BL-13, UCRU-BL-17, UCRU-BL-28, 5637, T24 J82, were studied using an in vitro proliferation assay. Effects following exposure to BCG or IFNα2b analysed by [3H]thymidine incorporation over 7 days. had antiproliferative effect all while sensitivity varied greatly, being as remarkably low 1 U/ml for some lines. The was greatest when cells exposed continuously either agent, but still evident with a limited exposure. When clinical concentrations simulated vitro, BCG+IFNα2b more effective than alone double concentration. We conclude that, addition their immunomodulatory effects, directly inhibit the cancer cells, often at extremely concentrations.
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