Therapeutic strategies for esophagogastric junction cancer

摘要: Summary The incidence and prevalence of esophagogastric junction (EGJ) cancer have increased in Western Asian countries recent decades. However, previous studies on the classification, surgical treatment, multimodal therapy relation to these tumors indicated multiple inconsistencies. Despite their single anatomical location stage, EGJ cancer-related are scarce, because patient cases with typically examined esophageal gastric treatment trials. improvements radiotherapy techniques refinements chemotherapeutic regimens, long-term survival patients remains poor. Surgical resection is only standard approach for early stage disease (Stage I). primary goal operation complete removal tumor its lymphatic drainage. Treatment approaches localized, resectable based tumors, histology, comorbidities; however, surgery fundamental Stage II–III cancer, multimodality chemotherapy or chemoradiotherapy uncertain. This review focuses approaches, provides an overview evidence perioperative role targeted therapies ongoing clinical trials regarding cancer.