Clinical, Histopathologic, and Biologic Features of Pleomorphic Lobular (Ductal-Lobular) Carcinoma In Situ of the Breast: A Report of 24 Cases

摘要: We reviewed 10 cases of pleomorphic lobular (ductal lobular) carcinoma in situ (PL/DLCIS) the breast and compared them with 14 (PLCIS) found association invasive carcinoma. The histologic features; immunohistochemical staining for estrogen receptors (ERs), p53, Ki67, E-cadherin, gross cystic disease fluid protein-15 (GCDFP-15); results fluorescence hybridization HER-2/neu gene amplification were evaluated all 24 cases. Histologically, PL/DLCIS cells similar to those PLCIS invasion that they discohesive medium large size moderate marked nuclear pleomorphism, small prominent nucleoli, abundant eosinophilic or vacuolated cytoplasm. In both groups, central necrosis was present a number cases, classic LCIS coexisted lesion less than half cases; carcinomas positive ERs 23 (100%) p53 6 (25%) GCDFP-15 (74%) 19 percentage Ki67-positive tumor nuclei indicated high (more 20%) proliferative activity 8 (47%) 17 Immunostaining E-cadherin negative observed 1 (4%) associated invasion, had cytologic features immunostaining patterns component. Seven patients who without underwent lumpectomy simple mastectomy. Six these no evidence follow-up periods ranging from 4 32 months; seventh patient developed recurrent 12 months after undergoing lumpectomy. conclude biomarker expression profile are but somewhat different ductal situ. Long-term studies needed further define natural history its optimal management.