Triple-helix forming oligonucleotides for targeted mutagenesis
作者： Peter M. Glazer
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摘要: A high affinity, triplex-forming oligonucleotide and methods for use thereof wherein an is used to form a triple-stranded nucleic acid molecule with specific DNA segment of target molecule. Upon formation the triplex, binding stimulates mutagenesis within or adjacent sequence using cellular synthesis repair mechanisms thereby producing heritable changes in human animal. The mutation activates, inactivates alters activity function This may be result recombinagenic mechanism induced by oligonucleotide.
lens.org 参考文章(67)
M Grigoriev, D Praseuth, P Robin, A Hemar, T Saison-Behmoaras, A Dautry-Varsat, N.T. Thuong, C Hélène, A Harel-Bellan, A triple helix-forming oligonucleotide-intercalator conjugate acts as a transcriptional repressor via inhibition of NF kappa B binding to interleukin-2 receptor alpha-regulatory sequence. Journal of Biological Chemistry. ,vol. 267, pp. 3389- 3395 ,(1992) , 10.1016/S0021-9258(19)50743-8
P A Havre, P M Glazer, Targeted mutagenesis of simian virus 40 DNA mediated by a triple helix-forming oligonucleotide. Journal of Virology. ,vol. 67, pp. 7324- 7331 ,(1993) , 10.1128/JVI.67.12.7324-7331.1993
James Zweighaft, Power-off motor deceleration control system ,(1994)
Pamela A. Whitney Avenue Havre, Peter M. Glazer, Chemically modified oligonucleotide for site-directed mutagenesis ,(1994)
Paul O.P. Ts'o, Paul S. Miller, Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids ,(1987)
Donald Joseph Kessler, Michael Edward Hogan, Method for making synthetic oligonucleotides which bind specifically to target sites on duplex dna molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use ,(1989)
F L Lin, K M Sperle, N L Sternberg, Extrachromosomal recombination in mammalian cells as studied with single- and double-stranded DNA substrates. Molecular and Cellular Biology. ,vol. 7, pp. 129- 140 ,(1987) , 10.1128/MCB.7.1.129
Jacques R. Fresco, Triple-stranded nucleic acids ,(1992)
P M Glazer, S N Sarkar, G E Chisholm, W C Summers, DNA mismatch repair detected in human cell extracts. Molecular and Cellular Biology. ,vol. 7, pp. 218- 224 ,(1987) , 10.1128/MCB.7.1.218
Carine Giovannangéli, Nguyen T. Thuong, Claude Héléne, Oligodeoxynucleotide-directed photo-induced cross-linking of HIV proviral DNA via triple-helix formation Nucleic Acids Research. ,vol. 20, pp. 4275- 4281 ,(1992) , 10.1093/NAR/20.16.4275