Modulation of sphingosine 1-phosphate and tyrosine hydroxylase in the stress-induced anxiety.

摘要: Stress causes endocrinological changes and leads to induce anxiety. It was determined the anxiety stress-related through observation of level glucocorticoid sphingolipid metabolites in serum after stress. Immobilized stress electric shock applied rats for 7 days. This study investigated induction anxiety, TH pERK expression cortex amygdala Also it when were given lesion. The stress-given spent a lesser percentage time significantly open arm than control rats. elevated suppressed lesion group. decreased, but not changed To investigate stress, levels sphingosine phosphate form (So-1-P) analyzed serum. So-1-P observed infusion (100 pmol/10 μl/h, i.c.v., days). Continuous days led significant decrease amygdala. In conclusion, results this indicate that stress-induced elevation also as well increased might be responsible biomarker, at least part, chronic These suggest involved during by modulation dopaminergic system