Population structure and antimicrobial susceptibility of Mycoplasma ovipneumoniae isolates in France.

摘要: Chronic non-progressive pneumonia in small ruminants caused by Mycoplasma (M.) ovipneumoniae is mainly controlled chemotherapy. In France, during the last decade, a rise M. cases was recorded both sheep and goats, suggesting possible emergence. Whether this associated with antimicrobial resistance, as observed other ruminant species, has yet to be examined. The aim of study characterize diversity strains circulating France assess their together underlying mechanisms, help find an explanation for increase reported cases. genetic 56 isolated between 2007 2018 from goats assessed using different subtyping methods. Their susceptibility six classes profiled estimating Minimum Inhibitory Concentrations (MICs) optimised agar dilution method. Resistance mechanisms were explored sequence analysis rRNA targets. A high evidenced, consistent, marked animal-host clustering Hsp70 gene whole genome phylogeny. No clonal evolution could thus account putative Apart florfenicol, MICs low except few isolates increased values tetracyclines, macrolides lincosamides. Hotspot mutations target ribosomal explain tetracycline MICs. Other are suspected macrolide-lincosamide florfenicol resistance. emergence not related any resistance or spread. Explanations may lie breeding practices.