Antioxidant and Vasodilator Activity of Ugni molinae Turcz. (Murtilla) and Its Modulatory Mechanism in Hypotensive Response

摘要: Hypertension is a systemic condition with high morbidity and mortality rates worldwide, which poses an increased risk for cardiovascular diseases. In this study, we demonstrated the antioxidant vasodilator activity of Ugni molinae Turcz. (Murtilla) fruit, berry native to Chile proposed models explain its modulatory mechanism in hypotensive response. Murtilla fruits were cultivated germplasm bank submitted chemical biological analyses. The phenolic compounds gallic acid, Catechin, Quercetin-3-β-D-glucoside, Myricetin, Quercetin, Kaempferol identified. extract did not generate toxic effects on human endothelial cells had significant against ROS production, lipid peroxidation, superoxide anion production. Furthermore, it showed dose-dependent aortic rings presence endothelium, whose partially mediated by nitric oxide synthase/guanylate cyclase large-conductance calcium-dependent potassium channels. might potentially have beneficial management