Coronavirus Transcription: A Perspective

摘要: At the VIth International Symposium on Corona and Related Viruses held in Quebec, Canada 1994 we presented a new model for coronavirus transcription to explain how subgenome-length minus strands, which are used as templates synthesis of subgenomic mRNAs, might arise by process involving discontinuous RNA synthesis. The old explaining mRNA synthesis, was called leader-primed transcription, based erroneous evidence that only genome-length negative strands were present replicative intermediates. To discovery related model, replicon proposed: mRNAs would be produced initially then replicated into minus-strand turn transcribed mRNAs. We review experimental led us formulate third proposing event occurs during strand With our genome is copied both continuously produce discontinuously do not function does.