Exposure to particulate air pollution during early pregnancy is associated with placental DNA methylation

摘要: Maternal exposure to particulate matter with aerodynamic diameter <10μm (PM10) during pregnancy results in adverse birth outcomes. Changes placental DNA methylation might mediate those effects. In this study, we examined the associations between prenatal PM10 and of LINE1, HSD11B2 NR3C1 human placenta. One hundred eighty-one mother newborn pairs (80 fetal growth restriction newborns, 101 normal newborns) participated study. The average each trimester whole was calculated using daily air pollution concentration data. Placental measured by quantitative polymerase chain reaction-pyrosequencing. LINE-1 reversely associated first 1.78% (-β=1.78, 95% CI: -3.35, -0.22%), while both second exposure, relatively increased 1.03% (95% 0.07, 1.98%) 2.33% 0.69, 3.76%) for 10μg/m3 increase PM10. Those were much more evident newborns than newborns. summary, early LINE1 HSD11B2, suggesting that such alterations PM-induced reproductive developmental toxicity.