THE EFFECT OF CIGARETTE SMOKING ON BLADDER CARCINOGENS IN MAN.
作者： P. E. Levers , Z. Menczyk , M. Barkin , S. K.-C. Woo , W. K. Kerr
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摘要: In the metabolism of amino acid, tryptophan, certain products with orthoaminophenol configuration are believed to act as topical carcinogens in urinary bladder. addition, a statistical relationship between cigarette smoking and bladder cancer has been established recent years.Thirty metabolic studies reported on six healthy male subjects when not smoking. Results revealed consistent rise carcinogenic metabolites tryptophan (+ 50%), reciprocal fall end product, N'-methylnicotinamide (- 34%). Carcinogens fell rose stopped These confirm cancer, suggest that blocks normal leading accumulation metabolites.
cabdirect.org参考文章(16)
Harold F. Dorn, Tobacco consumption and mortality from cancer and other diseases. Public Health Reports. ,vol. 74, pp. 581- 593 ,(1959) , 10.2307/4590516
E. Boyland, D. C. Williams, The metabolism of tryptophan. 2. The metabolism of tryptophan in patients suffering from cancer of the bladder* Biochemical Journal. ,vol. 64, pp. 578- 582 ,(1956) , 10.1042/BJ0640578
D Coppini, C A Benassi, M Montorsi, Quantitative Determination of Tryptophan Metabolites (via Kynurenine) in Biologic Fluids Clinical Chemistry. ,vol. 5, pp. 391- 401 ,(1959) , 10.1093/CLINCHEM/5.5.391
W. K. Kerr, M. Barkin, I. A. D. Todd, Z. Menczyk, A HYPERNEPHROMA ASSOCIATED WITH ELEVATED LEVELS OF BLADDER CARCINOGENS IN THE URINE: CASE REPORT1 BJUI. ,vol. 35, pp. 263- 266 ,(1963) , 10.1111/J.1464-410X.1963.TB06903.X
R. Doll, A. B. Hill, Lung Cancer and Other Causes of Death in Relation to Smoking BMJ. ,vol. 2, pp. 1071- 1081 ,(1956) , 10.1136/BMJ.2.5001.1071
S.L. Tompsett, The determination in urine of some metabolites of tryptophan-kynurenine, anthranilic acid and 3-hydroxyanthranilic acid-and reference to the presence of o-aminophenol in urine Clinica Chimica Acta. ,vol. 4, pp. 411- 419 ,(1959) , 10.1016/0009-8981(59)90112-3
O. Pelletier, J.A. Campbell, A rapid method for the determination of N'-methylnicotinamide in urine. Analytical Biochemistry. ,vol. 3, pp. 60- 67 ,(1962) , 10.1016/0003-2697(62)90044-1
Ernest L. Wynder, John Onderdonk, Nathan Mantel, An epidemiological investigation of cancer of the bladder Cancer. ,vol. 16, pp. 1388- 1407 ,(1963) , 10.1002/1097-0142(196311)16:11<1388::AID-CNCR2820161104>3.0.CO;2-8
Lars R. Holsti, Pentti Ermala, Papillary carcinoma of the bladder in mice, obtained after peroral administration of tobacco tar Cancer. ,vol. 8, pp. 679- 682 ,(1955) , 10.1002/1097-0142(1955)8:4<679::AID-CNCR2820080405>3.0.CO;2-W
D B Clayson, J W Jull, G M Bonser, The Testing of Ortho Hydroxy-Amines and Related Compounds by Bladder Implantation and a Discussion of their Structural Requirements for Carcinogenic Activity British Journal of Cancer. ,vol. 12, pp. 222- 230 ,(1958) , 10.1038/BJC.1958.26