The translational landscape of mTOR signalling steers cancer initiation and metastasis
作者： Andrew C. Hsieh , Yi Liu , Merritt P. Edlind , Nicholas T. Ingolia , Matthew R. Janes
DOI: 10.1038/NATURE10912
关键词:
摘要: … site inhibitors on prostate cancer cell migration and invasion. We … determine the functional role of YB1 in prostate cancer cell invasion, we silenced YB1 gene expression in PC3 cells…
nature.com
harvard.edu
ucsf.edu 参考文章(40)
Brent W Sutherland, Jill Kucab, Joyce Wu, Cathy Lee, Maggie C U Cheang, Erika Yorida, Dmitry Turbin, Shoukat Dedhar, Colleen Nelson, Michael Pollak, H Leighton Grimes, Kathy Miller, Sunil Badve, David Huntsman, C Blake-Gilks, Min Chen, Catherine J Pallen, Sandra E Dunn, Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells Oncogene. ,vol. 24, pp. 4281- 4292 ,(2005) , 10.1038/SJ.ONC.1208590
Tatsuya Okuzumi, Dorothea Fiedler, Chao Zhang, Daniel C Gray, Brian Aizenstein, Randy Hoffman, Kevan M Shokat, Inhibitor Hijacking of Akt Activation Nature Chemical Biology. ,vol. 5, pp. 484- 493 ,(2009) , 10.1038/NCHEMBIO.183
Ping Zhou, Ming-Hui Chen, David McLeod, Peter R. Carroll, Judd W. Moul, Anthony V. D’Amico, Predictors of Prostate Cancer–Specific Mortality After Radical Prostatectomy or Radiation Therapy Journal of Clinical Oncology. ,vol. 23, pp. 6992- 6998 ,(2005) , 10.1200/JCO.2005.01.2906
Xi Wang, Marianna Kruithof-de Julio, Kyriakos D. Economides, David Walker, Hailong Yu, M. Vivienne Halili, Ya-Ping Hu, Sandy M. Price, Cory Abate-Shen, Michael M. Shen, A luminal epithelial stem cell that is a cell of origin for prostate cancer Nature. ,vol. 461, pp. 495- 500 ,(2009) , 10.1038/NATURE08361
Annabelle Grolleau, Jessica Bowman, Bérengère Pradet-Balade, Eric Puravs, Samir Hanash, Jose A. Garcia-Sanz, Laura Beretta, Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics. Journal of Biological Chemistry. ,vol. 277, pp. 22175- 22184 ,(2002) , 10.1074/JBC.M202014200
Matthias D. Hofer, Rainer Kuefer, Sooryanarayana Varambally, Haojie Li, Jing Ma, Geoffrey I. Shapiro, Juergen E. Gschwend, Richard E. Hautmann, Martin G. Sanda, Klaudia Giehl, Andre Menke, Arul M. Chinnaiyan, Mark A. Rubin, The Role of Metastasis-Associated Protein 1 in Prostate Cancer Progression Cancer Research. ,vol. 64, pp. 825- 829 ,(2004) , 10.1158/0008-5472.CAN-03-2755
D. J. Mulholland, L. Xin, A. Morim, D. Lawson, O. Witte, H. Wu, Lin−Sca-1+CD49fhigh Stem/Progenitors Are Tumor-Initiating Cells in the Pten-Null Prostate Cancer Model Cancer Research. ,vol. 69, pp. 8555- 8562 ,(2009) , 10.1158/0008-5472.CAN-08-4673
Anne-Claude Gingras, Brian Raught, Nahum Sonenberg, Regulation of translation initiation by FRAP/mTOR Genes & Development. ,vol. 15, pp. 807- 826 ,(2001) , 10.1101/GAD.887201
Valentina Evdokimova, Cristina Tognon, Tony Ng, Peter Ruzanov, Natalya Melnyk, Dieter Fink, Alexey Sorokin, Lev P. Ovchinnikov, Elai Davicioni, Timothy J. Triche, Poul H.B. Sorensen, Translational Activation of Snail1 and Other Developmentally Regulated Transcription Factors by YB-1 Promotes an Epithelial-Mesenchymal Transition Cancer Cell. ,vol. 15, pp. 402- 415 ,(2009) , 10.1016/J.CCR.2009.03.017
Can Liu, Kevin Kelnar, Bigang Liu, Xin Chen, Tammy Calhoun-Davis, Hangwen Li, Lubna Patrawala, Hong Yan, Collene Jeter, Sofia Honorio, Jason F Wiggins, Andreas G Bader, Randy Fagin, David Brown, Dean G Tang, The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44 Nature Medicine. ,vol. 17, pp. 211- 215 ,(2011) , 10.1038/NM.2284