CD24 blunts oral squamous cancer development and dampens the functional expansion of myeloid-derived suppressor cells.

摘要: CD24 expression has been implicated in the oncogenesis of multiple types cancer and high tumor is considered a poor prognosis factor; however, role oral progression unknown. Unlike other types, we found that higher levels human cancers are correlated to lower clinical stage better overall survival. We then dissected mechanisms pathogenesis mice using genetic strategy demonstrated deficiency increased cavity burden response carcinogen 4-nitroquioline 1-oxide (4-NQO). Immune profile analysis showed significant expansion as well suppressive function myeloid-derived suppressor cells (MDSCs) CD24-/- mice, but no apparent impairment T cells, B or dendritic cells. Further, studies with an orthotopically transplanted syngeneic squamous carcinoma model tongue CD24+/- confirmed protective roles against cancer. Moreover, difference growth between was blunted by immunodepletion MDSCs. conclude impedes MDSC function, thus slows oncogenesis. This study first examine de novo model, it highlights need consider immune regulatory development CD24-targeted therapy for