The Evolution of an Enzyme
作者： DAVID M. BONNER , J.A. DEMOSS , STANLEY E. MILLS
DOI: 10.1016/B978-1-4832-2734-4.50028-0
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摘要: Publisher Summary This chapter discusses the evolution of an enzyme. The results gathered from various sources comparative studies on primary structure specific proteins have provided raw material for speculations nature variations that occurred at biochemical level during evolution. Such invoke notion mutations, leading to alterations in specificity or stability proteins, are preserved eliminated by natural selective forces. is based knowledge gene–enzyme relationships mutations can lead alteration substrate affinities, thermolability, sensitivity metal ions, and antigenic enzymes. interactions between distinct polypeptide chains important expression enzyme activities.
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