PPAR-α improves the recovery of lung function following acute respiratory distress syndrome by suppressing the level of TGF-β1

摘要: Although peroxisome proliferator-activated receptor (PPAR)-α has been reported to be involved in preventing acute lung injury (ALI), the molecular regulation of post‑ALI recovery remains fully elucidated. The aim present study was characterize mechanism by which PPAR‑α prevents ALI and examine role function following respiratory distress syndrome (ARDS). Reverse transcription‑quantitative‑polymerase chain reaction western blot analyses suggested that effective suppressing transforming growth factor (TGF)‑β1 HLF cells RAW 264.7 cells. In an mouse model, treatment prior stimulation with lipopolysaccharide (LPS) resulted a decrease expression TGF‑β1 bronchoalveolar lavage fluid (BALF), peripheral blood splenocytes. injection virus expressing short hairpin into mice LPS dose‑dependent increase resistance index dynamic compliance, significant BALF protein, indicated essential for ALI. Of note, serum inversely correlated negatively disease severity patients ARDS. These data suppression TGF‑β1, reveals previously unappreciated controlling recovery.