Consumer product in vitro digestion model: Bioaccessibility of contaminants and its application in risk assessment.

摘要: This paper describes the applicability of in vitro digestion models as a tool for consumer products (ad hoc) risk assessment. In current assessment, oral bioavailability from specific product is considered to be equal found toxicity studies which contaminants are usually ingested via liquids or food matrices. To become bioavailable, must first released during process (i.e. bioaccessible). Contaminants may less bioaccessible than liquid food. Therefore, actual after exposure could overestimated. simple, reliable, fast and relatively inexpensive method determining bioaccessibility contaminant product. Different models, representing sucking and/or swallowing were developed. The experimental design each model can adjusted appropriate scenarios determined by assessor. Several contaminated tested various models. Although relevant vivo data scare, we succeeded preliminary validate one case. case showed good correlation never underestimated bioavailability. However, validation check needs continued.