Characterization of an extended-spectrum class A β-lactamase from a novel enterobacterial species taxonomically related to Rahnella spp./Ewingella spp.

作者: Marie-Frédérique Lartigue , Patrice Nordmann , Mikhail V. Edelstein , Gaëlle Cuzon , Sylvain Brisse

DOI: 10.1093/JAC/DKT122

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摘要: Results: A chromosomal gene coding for the extended-spectrum b-lactamase (ESBL) SMO-1 was identified from a novel enterobacterial species that is taxonomically related to Rahnella aquatilis and Ewingella americana. The efficiently hydrolysed penicillins cefotaxime, shared 75% amino acid identity with plasmid-mediated SFO-1 Serratia fonticola, 74% ESBL CTX-M-2 originating Kluyvera spp. 72% chromosomally encoded intrinsic RAHN-1 R. aquatilis. Conclusions: We have recovered clinical specimen, constituting another potential source of acquired ESBL. significant similarities CTX-M-type enzymes.

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