Unravelling the biology of chromatin in health and cancer using proteomic approaches

摘要: ABSTRACTIntroduction: Chromatin remodeling complexes play important roles in the control of genome regulation both normal and diseased states, are therefore critical components for epigenetic states cells. Given role epigenetics plays cancer, example, chromatin routinely targeted therapeutic intervention.Areas covered: Protein mass spectrometry proteomics powerful technologies used to study understand remodeling. While impressive progress has been made this area, there remain significant challenges application proteomic As parts large multi-subunit that can be heavily modified with dynamic post-translational modifications, include defining content, determining regulation, studying dynamics under different cellular states.Expert commentary: Impwortant c...