Modulation of thalamocortical oscillations by TRIP8b, an auxiliary subunit for HCN channels

摘要: Hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels have important functions in controlling neuronal excitability and generating rhythmic oscillatory activity. The role of tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) regulation hyperpolarization-activated inward current, I h, the thalamocortical system its functional relevance for physiological oscillations were investigated. A significant decrease h current density, both relay (TC) cortical pyramidal neurons was found TRIP8b-deficient mice (TRIP8b-/-). In addition basal cAMP levels brain to be decreased while availability fast transient A-type K+ A, TC increased. These changes associated with alterations intrinsic properties firing patterns neurons, as well intrathalamic network oscillations, revealing a increase slow delta frequency range (0.5-4 Hz) during episodes active-wakefulness. addition, absence TRIP8b suppresses normal desynchronization response EEG switch from slow-wave sleep wakefulness. It is concluded that necessary modulation due direct effect on HCN channel expression thalamus cortex mechanisms related reduced signaling may contribute present findings.