Sensorimotor enhancement in mouse mutants lacking the Purkinje cell-specific Gi/o modulator, Pcp2(L7).

摘要: Pcp2(L7) is a GoLoco domain protein specifically and abundantly expressed in cerebellar Purkinje cells. It has been hypothesized to “tune” Gi/o-coupled receptor modulation of physiological effectors, including the P-type Ca2+ channel. We have analyzed mouse mutant which gene was inactivated find significant anatomical, behavioral electrophysiological changes. Anatomically, we observed mild hypoplasia. Behaviorally, mutants were altered modalities atypical for traditional mutant, oddly, all these changes could be considered functional enhancements. This includes increased asymptotic performance gross motor learning, rate acquisition tone-conditioned fear, enhanced pre-pulse inhibition acoustic startle response. Electrophysiological analysis cells reveals depression complex spike waveform that may underlie Based on observations suggest acts as sensorimotor damper modulates time- sense-dependent responses.