Measurement of gene expression profiles in toxicity determination

作者: Sydney Brenner

DOI:

关键词:

摘要: A method is provided for assessing the toxicity of a compound in test organism by measuring gene expression profiles selected tissues. Gene are measured massively parallel signature sequencing cDNA libraries constructed from mRNA extracted provide extensive information on effects administering to both acute tests and prolonged chronic tests.

参考文章(4)
Christine Debouck, Derk Bergsma, Martin Rosenberg, Differentially expressed genes in healthy and diseased subjects ,(1995)
Alexander B. Chetverin, Fred Russell Kramer, Oligonucleotide Arrays: New Concepts and Possibilities Bio/Technology. ,vol. 12, pp. 1093- 1099 ,(1994) , 10.1038/NBT1194-1093
S. Brenner, R. A. Lerner, Encoded combinatorial chemistry. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 5381- 5383 ,(1992) , 10.1073/PNAS.89.12.5381