Anemia in adenine-induced chronic renal failure and the influence of treatment with gum acacia thereon (1063.4)
作者： A. Nemmar , Mohammed Al Z'aabi , Badreldin Ali , A. Ramkumar
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摘要: Summary Anemia frequently complicates chronic kidney disease (CKD). We investigated here the effect of adenine-induced CKD in rats on erythrocyte count (EC), hematocrit (PCV) and hemoglobin (Hb) concentration, as well activity L-γ-glutamyl transferase (GGT) concentrations iron (Fe), transferrin (Tf), ferritin (F), total binding capacity (TIBC) / unsaturated (UIBC) hepcidin (Hp) serum erythropoietin (Epo) renal tissue. Renal damage was assessed histopathologically, also by measuring uremic toxin indoxyl sulfate (IS), creatinine, urea, creatinine clearance. influence concomitant treatment with gum acacia (GA) above analytes. Adenine feeding induced CKD, accompanied significant decreases (P<0.05) EC, PCV, Hb, Fe, Tf, TIBC, UIBC Epo. It increased Hp F levels. GA significantly ameliorated these changes CKD. A general improvement status after is shown due to its antiinflammatory anti-oxidant actions, reduction IS, which known suppress Epo production, this may be a reason for ameliorative actions indices anemia studied.
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