Update on the Colon Health and Life-Long Exercise Change Trial: A Phase III Study of the Impact of an Exercise Program on Disease-Free Survival in Colon Cancer Survivors

摘要: The Colon Health and Life-Long Exercise Change (CHALLENGE) trial is evaluating the effects of a 3-year exercise program on disease-free survival in 962 patients with resected high-risk stage II or III colon cancer. purpose this commentary to provide an update CHALLENGE trial. As December 31, 2013, had randomized 250 20 Canadian centers 26 Australian centers, further expansion planned. Early barriers accrual are reported strategies improve discussed. Of date, 89 % have cancer, 56 % were treated leucovorin/5-fluorouracil/oxaliplatin-based chemotherapy, 58 % body mass index at least 27.5 kg/m2, 53 % women, median age 60 years. remains only controlled cancer survivors that examining survival.