Physostigmine ameliorates the delusions of Alzheimer's disease.

作者: Jeffrey L. Cummings , David G. Gorman , Jill Shapira

DOI: 10.1016/0006-3223(93)90009-3

关键词:

摘要: Abstract Alzheimer's disease (AD) patients frequently manifest delusions, and the cholinergic deficiency of AD may contribute to this aspect psychopathology disorder. In a doubleblind, crossover study involving two patients, we compared antidelusional efficacy physostigmine, an acetylcholinesterase inhibitor, with haloperidol, widely used neuroleptic agent. Physostigmine ameliorated delusions produced fewer side effects. These preliminary observations suggest that contributes occurrence in therapy have role treatment delusional symptoms.

参考文章(28)
B. J. Sahakian, Cholinergic Drugs and Human Cognitive Performance Springer, Boston, MA. pp. 393- 424 ,(1988) , 10.1007/978-1-4613-0933-8_9
Susan D. Iversen, Solomon H. Snyder, Leslie L. Iversen, Psychopharmacology of the aging nervous system Plenum Press. ,(1988)
Henry A. Nasrallah, Fritz A. Henn, Schizophrenia as a brain disease Oxford University Press. ,(1982)
Kelly E. Lyons, William C. Koller, Rajesh Pahwa, Therapy of Parkinson's disease ,(1990)
Alan F Schatzberg, Anthony J Rothschild, Psychotic (delusional) major depression: should it be included as a distinct syndrome in DSM-IV? American Journal of Psychiatry. ,vol. 149, pp. 733- 745 ,(1992) , 10.1176/AJP.149.6.733
B Reisberg, A Georgotas, J Borenstein, E Franssen, S H Ferris, S P Salob, Behavioral symptoms in Alzheimer's disease: Phenomenology and treatment. The Journal of Clinical Psychiatry. ,vol. 48, pp. 9- 15 ,(1987)
Marshal F. Folstein, Susan E. Folstein, Paul R. McHugh, “Mini-mental state” Journal of Psychiatric Research. ,vol. 12, pp. 189- 198 ,(1975) , 10.1016/0022-3956(75)90026-6
Overview of depression and psychosis in Alzheimer's disease. American Journal of Psychiatry. ,vol. 146, pp. 577- 587 ,(1989) , 10.1176/AJP.146.5.577
Y. Stern, M. Sano, R. Mayeux, Long‐term administration of oral physostigmine in Alzheimer's disease Neurology. ,vol. 38, pp. 1837- 1837 ,(1988) , 10.1212/WNL.38.12.1837
Trey Sunderland, Pierre N. Tariot, Paul A. Newhouse, Differential responsivity of mood, behavior and cognition to cholinergic agents in elderly neuropsychiatric populations Brain Research. ,vol. 472, pp. 371- 389 ,(1988) , 10.1016/0165-0173(88)90013-6