作者: Jeffrey L. Cummings , David G. Gorman , Jill Shapira
DOI: 10.1016/0006-3223(93)90009-3
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摘要: Abstract Alzheimer's disease (AD) patients frequently manifest delusions, and the cholinergic deficiency of AD may contribute to this aspect psychopathology disorder. In a doubleblind, crossover study involving two patients, we compared antidelusional efficacy physostigmine, an acetylcholinesterase inhibitor, with haloperidol, widely used neuroleptic agent. Physostigmine ameliorated delusions produced fewer side effects. These preliminary observations suggest that contributes occurrence in therapy have role treatment delusional symptoms.