Neuroendocrine (Merkel cell) carcinoma of the skin.

摘要: Merkel cell carcinoma was diagnosed in 10 patients (eight females and two males) with a mean age of 66 years range 44-84. The most common sites the primary tumor were skin limbs, girdles, head. Sixty percent cases had recurrences 50% regional nodal metastases that appeared within 1 year. Of treated variably surgery, chemotherapy, radiotherapy followed for period 28 months, alive free disease, disease after 3 6 years, have died metastatic to lungs liver. lesions showed quite distinctive clinical gross features terms size, shape, color. Histologically, growth usually diffuse occasionally trabecular or pseudoglandular; infiltration predominantly papillary reticular dermis. uniform, poorly cohesive cells contained argyrophilic granules cytoplasm round oval nuclei frequently indented membranes. mitotic index high. Ultrastructurally, cases, types identified probably represented neoplastic counterpart normal different stages maturation. Both cytoplasmic neurosecretory intermediate filaments, even though their cytoplasms differently shaped.