An animal model of occupational immunologic asthma due to diphenylmethane diisocyanate, with multiple systemic immunologic responses.
作者： Pruzansky Jj , Patterson R , Harris Ke , Zeiss Cr
DOI: 10.5555/URI:PII:0022214382903080
关键词:
摘要: Inhalation of MDI in the plastics industry may produce hypersensitivity pneumonitis or immediate-type asthma workers. A suspension was given intrabronchially to dogs determine whether any clinical and immunologic human responses could be duplicated, Results showed that a systemic immune response MDI-DSA. Serum MDI-125I-DSA binding shown by ammonium sulfate technique. Antibody activity IgG, IgA, IgM antibody classes solid-phase enzyme-linked immunoassay. Precipitating antibodies were detected he dog serum against Immediate-type skin reactivity MDI-DSA consistent with canine IgE occurred. The appeared correlate an airway characterized increase pulmonary resistance after intrabronchial MDI. There transient peripheral blood lymphocyte results indicate large animal model is available for various immunopathogenic studies.
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