Obesity and Endometrial Cancer: Is There aRole for Immunotoxicity?

作者: Eftychia Karoutsou , Petros Karoutsos , Dimitrios Karoutsos

DOI: 10.21767/2472-1158.100032

关键词:

摘要: Chronic inflammation and obesity are reciprocal pathophysiological processes underlying the element of immune response. In obesity, alterations cytokines thought to contribute a low grade within adipose tissue affecting development several secondary diseases. Although micro-inflammation is involved in initiation response, excessive may promote tumor development. This review will discuss reflexive relationship between endometrial cancer through immunomodulatory effects exerted by environmental chemicals.

参考文章(42)
Monika Eichholzer, Holger Moch, Michela Ceschi, Nicole M Probst-Hensch, Felix Gutzwiller, Epidemiology and pathophysiology of obesity as cause of cancer. Swiss Medical Weekly. ,vol. 137, pp. 50- 56 ,(2007) , 10.5167/UZH-17805
Fagoaga Or, Nieman Dc, Rainwater Mk, Butterworth De, Henson Da, Warren Bj, Nehlsen-Cannarella Si, Immune response to obesity and moderate weight loss International Journal of Obesity. ,vol. 20, pp. 353- 360 ,(1996)
S.-I. Tanaka, M. Ishihara, S. Inoue, A. Sugiyama, M. Waseda, T. Yamakawa, K. Okuda, F. Isoda, Y. Takamura, Impaired immunity in obesity: suppressed but reversible lymphocyte responsiveness. International Journal of Obesity. ,vol. 17, pp. 631- 636 ,(1993)
George P. Chrousos, Edward O. Bixler, Alexandros N. Vgontzas, Dimitris A. Papanicolaou, Chronic systemic inflammation in overweight and obese adults. JAMA. ,vol. 283, pp. 2235- 2236 ,(2000) , 10.1001/JAMA.283.17.2235
P T Thomas, Pesticide-induced immunotoxicity: are Great Lakes residents at risk? Environmental Health Perspectives. ,vol. 103, pp. 55- 61 ,(1995) , 10.1289/EHP.95103S955
Carolina Bredhult, Lena Sahlin, Matts Olovsson, Gene expression analysis of human endometrial endothelial cells exposed to Bisphenol A. Reproductive Toxicology. ,vol. 28, pp. 18- 25 ,(2009) , 10.1016/J.REPROTOX.2009.03.006
Eugenia E. Calle, Rudolf Kaaks, Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms Nature Reviews Cancer. ,vol. 4, pp. 579- 591 ,(2004) , 10.1038/NRC1408
Kazumoto Katagiri, Shoko Arakawa, Rieko Kurahashi, Yutaka Hatano, Impaired contact hypersensitivity in diet-induced obese mice. Journal of Dermatological Science. ,vol. 46, pp. 117- 126 ,(2007) , 10.1016/J.JDERMSCI.2007.01.008
D. Trizio, D.A. Basketter, P.A. Botham, P.H. Graepel, Cl. Lambré, S.J. Magda, T.M. Pal, A.J. Riley, H. Ronneberger, N.J. Van Sittert, W.J. Bontinck, Identification of immunotoxic effects of chemicals and assessment of their relevance to man Food and Chemical Toxicology. ,vol. 26, pp. 527- 539 ,(1988) , 10.1016/0278-6915(88)90006-3
Ryungsa Kim, Manabu Emi, Kazuaki Tanabe, Cancer immunoediting from immune surveillance to immune escape Immunology. ,vol. 121, pp. 1- 14 ,(2007) , 10.1111/J.1365-2567.2007.02587.X