T-lymphoblastic leukemia/lymphoma.

摘要: Objectives To review important concepts from the 2013 Society for Hematopathology/European Association Haematopathology Workshop session on T-acute lymphoblastic leukemia/T-lymphoblastic lymphoma (T-ALL/T-LBL). Methods Twenty-one submitted cases are reviewed and summarized, with emphasis key diagnostic or biologic points, supplemented relevant literature citations. Results Early T-cell precursor (ETP)-ALL represented about one-third of all submitted. It is to recognize ETP-ALL, because these patients have a poor prognosis if treated standard therapy. A consensus immunophenotype has been developed aid in recognition cases. Other illustrated rare entities, including two Philadelphia chromosome–positive T-ALL, T-ALL associated MYC translocations, single illustrating various diseases. subset issues related differential diagnosis T-ALL/T-LBL. Conclusions In view growing importance molecular genetic analysis T-ALL/T-LBL, it pathologists keep abreast developments. Currently, routine histopathology, immunophenotyping, conventional cytogenetic analysis, fluorescence situ hybridization, clonality testing usually adequate establish diagnosis. However, as therapies become more targeted, assessment abnormalities, either through candidate gene broad-scale unbiased approaches, may necessary.