PLP-dependent enzymes as potential drug targets for protozoan diseases.
作者： Barbara Kappes , Ivo Tews , Alexandra Binter , Peter Macheroux
DOI: 10.1016/J.BBAPAP.2011.07.018
关键词:
摘要: The chemical properties of the B(6) vitamers are uniquely suited for wide use as cofactors in essential reactions, such decarboxylations and transaminations. This review addresses current efforts to explore vitamin dependent enzymatic reactions drug targets. Several targets described that found amongst these enzymes. focus is set on diseases caused by protozoan parasites. Comparison across a range organisms allows insight into distribution potential targets, many which may be interest development broad anti-protozoan drugs. article part Special Issue entitled: Pyridoxal Phosphate Enzymology.
core.ac.uk
elsevier.com
sci-hub.se 参考文章(82)
S SATO, Enzymes for Heme Biosynthesis are Found in Both the Mitochondrion and Plastid of the Malaria Parasite Protist. ,vol. 155, pp. 117- 125 ,(2004) , 10.1078/1434461000169
Tomoyoshi Nozaki, Takashi Asai, Seiki Kobayashi, Fumio Ikegami, Masaaki Noji, Kazuki Saito, Tsutomu Takeuchi, Molecular cloning and characterization of the genes encoding two isoforms of cysteine synthase in the enteric protozoan parasite Entamoeba histolytica Molecular and Biochemical Parasitology. ,vol. 97, pp. 33- 44 ,(1998) , 10.1016/S0166-6851(98)00129-7
Laurent Meijer, Silvana Guidet, Lee Vogel, H.Y. Lim Tung, Michel Philippe, Progress in Cell Cycle Research ,(1999)
D. Bunnag, Heinz Mehlhorn, Parasitology in focus : facts and trends Springer-Verlag. ,(1988)
Tomoyoshi Nozaki, Vahab Ali, Masaharu Tokoro, [Sulfur-containing amino acid metabolism in parasitic protozoa]. Advances in Parasitology. ,vol. 60, pp. 1- 99 ,(2005) , 10.1016/S0065-308X(05)60001-2
Dan Sato, Wataru Yamagata, Shigeharu Harada, Tomoyoshi Nozaki, Kinetic characterization of methionine γ-lyases from the enteric protozoan parasite Entamoeba histolytica against physiological substrates and trifluoromethionine, a promising lead compound against amoebiasis FEBS Journal. ,vol. 275, pp. 548- 560 ,(2008) , 10.1111/J.1742-4658.2007.06221.X
Christian Burri, Reto Brun, Eflornithine for the treatment of human African trypanosomiasis. Parasitology Research. ,vol. 90, ,(2003) , 10.1007/S00436-002-0766-5
M W Simon, E Martin, A J Mukkada, Evidence for a functional glyoxylate cycle in the leishmaniae. Journal of Bacteriology. ,vol. 135, pp. 895- 899 ,(1978) , 10.1128/JB.135.3.895-899.1978
R. Sutak, P. Dolezal, H. L. Fiumera, I. Hrdy, A. Dancis, M. Delgadillo-Correa, P. J. Johnson, M. Muller, J. Tachezy, Mitochondrial-type assembly of FeS centers in the hydrogenosomes of the amitochondriate eukaryote Trichomonas vaginalis Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 10368- 10373 ,(2004) , 10.1073/PNAS.0401319101
Nick V. Grishin, Andrei L. Osterman, Harold B. Brooks, Margaret A. Phillips, Elizabeth J. Goldsmith, X-ray structure of ornithine decarboxylase from Trypanosoma brucei: the native structure and the structure in complex with alpha-difluoromethylornithine. Biochemistry. ,vol. 38, pp. 15174- 15184 ,(1999) , 10.1021/BI9915115