Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease.
作者： Jose Bras , Andrew Singleton , Mark R. Cookson , John Hardy
DOI: 10.1111/J.1742-4658.2008.06709.X
关键词:
摘要: Heterozygous loss-of-function mutations at the glucosecerebrosidase locus have recently been shown to be a potent risk factor for Lewy body disease. Based on this observation, we re-evaluated likelihood that different PARK loci (defined using clinical criteria disease) may misleading attempts find common pathways pathogenesis. Rather, suggest, grouping which lead disease more revealing. Doing this, suggest several of genes involved in disparate diseases impinge ceramide metabolism and theme
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