Effects of 4-(3-Chloro-Benzyl)-6,7-Dimethoxy-Quinazoline on Kinetics of P120-Catenin and Periplakin in Human Buccal Mucosa Squamous Carcinoma Cell Line
作者： Isao Tamura , Aiko Kamada , Seiji Goda , Yoshihiro Yoshikawa , Eisuke Domae
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摘要: In order to detect molecular markers for the epidermal growth factor inhibitor 4-(3-chloro-benzyl)- 6,7-dimethoxy-quinazoline (tyrphostin), we investigated kinetics of p120-catenin and periplakin in human buccal mucosa squamous cancer cell line BICR 10 treated with 3 nM tyrphostin. Growth cells was inhibited by treatment Although changes were not observed expression EGFR p120-catenin, Akt, Src tyrphostin tended decrease. addition, phosphorylation EGFR, Akt On immunocytochemical staining, immunoreactions phosphorylated weak There a slight immunocy chemical reaction induced conclusion, decrease tyrphostin, following or phosphorylation, may inhibit several factors associated proliferation migration cells.
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