Paclitaxel by 1-hour infusion: an active drug in metastatic non-small-cell lung cancer.
作者： J D Hainsworth , D S Thompson , F A Greco
DOI: 10.1200/JCO.1995.13.7.1609
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摘要: PURPOSEPaclitaxel is an active single agent when administered as a 24-hour continuous infusion in the treatment of stage IV non-small-cell lung cancer. We evaluated efficacy and toxicity paclitaxel by 1-hour outpatient setting to patients with or relapsed cancer.PATIENTS AND METHODSFifty-nine cancer were treated infusions paclitaxel. The first 17 received dose 135 mg/m2 remaining 42 200 mg/m2. By random assignment, 31 single-day, paclitaxel, 28 3-day, divided-dose schedule, each infusion. Both regimens repeated every 21 days. All premedication dexamethasone, diphenhydramine, cimetidine. Cytokines not routinely used.RESULTSThirteen 53 assessable (25%) had partial responses treatment. An ad...
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