Retinotopic maps and foveal suppression in the visual cortex of amblyopic adults

摘要: Amblyopia is a developmental visual disorder associated with loss of monocular acuity and sensitivity as well profound alterations in binocular integration. Abnormal connections cortex are known to underlie this loss, but the extent which these abnormalities regionally or retinotopically specific has not been fully determined. This functional magnetic resonance imaging (fMRI) study compared retinotopic maps produced by each individual eye 19 adults (7 esotropic strabismics, 6 anisometropes controls). In our standard viewing condition, non-tested viewed dichoptic homogeneous mid-level grey stimulus, thereby permitting some degree interaction. Regions-of-interest analysis was performed for extrafoveal V1, V2 foveal representation at occipital pole. general, blood oxygenation level-dependent (BOLD) signal reduced amblyopic eye. At pole, population receptive fields were shifted represent more parafoveal locations eye, fellow subjects. Interestingly, occluding caused an expanded one early–onset strabismic subject suppression, indicating real-time cortical remapping. addition, few subjects actually showed increased activity parietal temporal when We conclude that, even heterogeneous population, abnormal early experience commonly leads adaptations.