ANTI-HtrA1 ANTIBODIES AND METHODS OF USE
作者： Michael Terry Lipari , Scott Stawicki , Daniel Kirchhofer , Paul M Moran , Wei-Ching Liang
DOI:
关键词:
摘要: The invention provides anti-HtrA1 antibodies and methods of using the same antibody a method diagnozing treating target diseases therewith. Especially, separated antibody, which can be combined with HtrA1, wherein antibody: (i) epitopes N224, K248 or both including dissociation constant beingnot more than 500 nM; (ii) inhibit activity HtrA1 serine protease. treat individual such as age-related macular degeneration, geographic atrophy, diabetic retinopathy, premature infant polypus-like choroid angiosis.
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