Retinoic Acid Is Present in the Postnatal Rat Olfactory Organ and Persists in Vitamin A–Depleted Neural Tissue

摘要: Vitamin A (VA), all-trans-retinol (at-ROL), and its derivative, all-trans-retinoic acid (at-RA), are required for neuron development. The effects of these retinoids dependent upon the nutritional status rat tissue-specific dynamics retinoid access utilization. purpose this study was to determine at-ROL at-RA in peripheral olfactory organ postnatal rats fed a normal diet VA-deficient (VAD) diet. Extracted were analyzed by HPLC. Resolved sample peaks identified comparing their elution times spectra with those authentic standards. Mean concentrations 23 pmol/g tissue 0.13 nmol/g, respectively, recovered from tissue. ratio at-RA:at-ROL approximately 2 that testis 200 liver. depleted liver VAD birth 70 d age. Surprisingly, still present rats. At 90 age, frankly deficient no longer detectable comparatively high persistence at-ROL-depleted tissues strongly suggests maintenance local stores is functionally relevant