Long-Term Outcomes and Risk Factors Associated With Acute Encephalitis in Children.

作者: Suchitra Rao , Benjamin Elkon , Kelly B. Flett , Angela F. D. Moss , Timothy J. Bernard

DOI: 10.1093/JPIDS/PIV075

关键词:

摘要: Background Factors associated with poor outcomes of children encephalitis are not well known. We sought to determine whether electroencephalography (EEG) findings, magnetic resonance imaging (MRI) abnormalities, or the presence seizures at presentation were outcomes. Methods A retrospective review patients aged 0 21 years who met criteria for a diagnosis admitted between 2000 and 2010 was conducted. Parents eligible contacted completed 2 questionnaires that assessed current physical emotional quality life neurological deficits least 1 year after discharge. Results During study period, we identified 142 an International Classification Diseases 9th Revision meningitis, meningoencephalitis, encephalitis. Of these patients, 114 encephalitis, 76 (representing 77 hospitalizations) had complete data available. Forty-nine (64%) available follow-up. Patients intensive care unit more likely have abnormal EEG results (P = .001). The on admission ongoing seizure disorder One hospitalization, 78% persistent symptoms, including 35% seizures. Four (5%) died. Abnormal MRI findings number initial lower quality-of-life scores. Conclusions Encephalitis leads significant morbidity death, incomplete recovery is achieved in majority hospitalized patients. found frequently critically ill children, scores follow-up,

参考文章(25)
Richard Whitley, Ann Arvin, Charles Prober, Lawrence Corey, Sandra Burchett, Stanley Plotkin, Stuart Starr, Richard Jacobs, Dwight Powell, Andre Nahmias, Ciro Sumaya, Kathryn Edwards, Charles Alford, Gary Caddell, Seng-Jaw Soong, , Predictors of Morbidity and Mortality in Neonates with Herpes Simplex Virus Infections New England Journal of Medicine. ,vol. 324, pp. 450- 454 ,(1991) , 10.1056/NEJM199102143240704
Asif Doja, Ari Bitnun, Elizabeth Lee Ford Jones, Susan Richardson, Raymond Tellier, Martin Petric, Helen Heurter, Daune MacGregor, Pediatric Epstein-Barr virus-associated encephalitis: 10-year review. Journal of Child Neurology. ,vol. 21, pp. 384- 391 ,(2006) , 10.1177/08830738060210051101
A. Schmidt, R. Bühler, K. Mühlemann, C.W. Hess, M.G. Täuber, Long-term outcome of acute encephalitis of unknown aetiology in adults. Clinical Microbiology and Infection. ,vol. 17, pp. 621- 626 ,(2011) , 10.1111/J.1469-0691.2010.03276.X
James W. Varni, Christine A. Limbers, Katie Neighbors, Kris Schulz, Judith E. C. Lieu, Robert W. Heffer, Krista Tuzinkiewicz, Rita Mangione-Smith, Jerry J. Zimmerman, Estella M. Alonso, The PedsQL™ Infant Scales: feasibility, internal consistency reliability, and validity in healthy and ill infants Quality of Life Research. ,vol. 20, pp. 45- 55 ,(2011) , 10.1007/S11136-010-9730-5
LUAN-YIN CHANG, SHAO-HSUAN HSIA, CHANG-TENG WU, YHU-CHERING HUANG, KUANG-LIN LIN, TSUI-YEN FANG, TZOU-YIEN LIN, Outcome of enterovirus 71 infections with or without stage-based management: 1998 to 2002. Pediatric Infectious Disease Journal. ,vol. 23, pp. 327- 331 ,(2004) , 10.1097/00006454-200404000-00010
Susan K. Klein, David L. Hom, Michael R. Anderson, Anne T. Latrizza, Philip Toltzis, Predictive factors of short-term neurologic outcome in children with encephalitis Pediatric Neurology. ,vol. 11, pp. 308- 312 ,(1994) , 10.1016/0887-8994(94)90007-8
M. Koskiniemi, M. Korppi, K. Mustonen, H. Rantala, M. Muttilainen, E. Herrgård, P. Ukkonen, A. Vaheri, Epidemiology of encephalitis in children. A prospective multicentre study. European Journal of Pediatrics. ,vol. 156, pp. 541- 545 ,(1997) , 10.1007/S004310050658
U.K. Misra, J. Kalita, Seizures in encephalitis: Predictors and outcome Seizure-european Journal of Epilepsy. ,vol. 18, pp. 583- 587 ,(2009) , 10.1016/J.SEIZURE.2009.06.003
I-Jen Wang, Ping-Ing Lee, Li-Ming Huang, Chien-Jen Chen, Chi-Ling Chen, Wang-Tso Lee, The correlation between neurological evaluations and neurological outcome in acute encephalitis: a hospital-based study. European Journal of Paediatric Neurology. ,vol. 11, pp. 63- 69 ,(2007) , 10.1016/J.EJPN.2006.09.010
Mona-Lisa Engman, Ingrid Adolfsson, Ilona Lewensohn-Fuchs, Marianne Forsgren, Mikael Mosskin, Gunilla Malm, Neuropsychologic Outcomes in Children With Neonatal Herpes Encephalitis Pediatric Neurology. ,vol. 38, pp. 398- 405 ,(2008) , 10.1016/J.PEDIATRNEUROL.2008.02.005