Endogenous Elevation of Homocysteine Induces Retinal Neuron Death in the Cystathionine-β-Synthase Mutant Mouse

作者: Preethi S. Ganapathy , Brent Moister , Penny Roon , Barbara A. Mysona , Jennifer Duplantier

DOI: 10.1167/IOVS.09-3402

关键词:

摘要: Purpose To determine the effects of endogenous elevation homocysteine on retina using cystathionine β-synthase (cbs) mutant mouse.

参考文章(57)
Jacob Selhub, Public health significance of elevated homocysteine. Food and Nutrition Bulletin. ,vol. 29, ,(2008) , 10.1177/15648265080292S116
PAUL A. MOORE, JANICE C. ZGIBOR, ANANDA P. DASANAYAKE, Diabetes: a growing epidemic of all ages. Journal of the American Dental Association. ,vol. 134, ,(2003) , 10.14219/JADA.ARCHIVE.2003.0369
R N Lolley, The rd gene defect triggers programmed rod cell death. The Proctor Lecture. Investigative Ophthalmology & Visual Science. ,vol. 35, pp. 4182- 4191 ,(1994)
Juming Lu, Changyu Pan, Guoqing Yang, The impact of plasma homocysteine level on development of retinopathy in type 2 diabetes mellitus Chinese Journal of Internal Medicine. ,vol. 41, pp. 34- ,(2002)
Dongxian Zhang, Stuart A. Lipton, L-homocysteic acid selectively activates N-methyl-D-aspartate receptors of rat retinal ganglion cells. Neuroscience Letters. ,vol. 139, pp. 173- 177 ,(1992) , 10.1016/0304-3940(92)90545-I
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Jacob Selhub, Laura C Bagley, Joshua Miller, Irwin H Rosenberg, B vitamins, homocysteine, and neurocognitive function in the elderly The American Journal of Clinical Nutrition. ,vol. 71, ,(2000) , 10.1093/AJCN/71.2.614S
Efthymia K. Tsina, Maculopathy and Retinal Degeneration in Cobalamin C Methylmalonic Aciduria and Homocystinuria Archives of Ophthalmology. ,vol. 123, pp. 1143- 1146 ,(2005) , 10.1001/ARCHOPHT.123.8.1143
Jessie Yanxiang Guo, Ayumi Yamada, Taisuke Kajino, Judy Qiju Wu, Wanli Tang, Christopher D. Freel, Junjie Feng, B. Nelson Chau, Michael Zhuo Wang, Seth S. Margolis, Hae Yong Yoo, Xiao-Fan Wang, William G. Dunphy, Pablo M. Irusta, J. Marie Hardwick, Sally Kornbluth, Aven-Dependent Activation of ATM Following DNA Damage Current Biology. ,vol. 18, pp. 933- 942 ,(2008) , 10.1016/J.CUB.2008.05.045