A Retrospective Study on Amoxicillin Susceptibility in Severe Haemophilus influenzae Pneumonia.
作者： Frank Pourcine , Sebastien Jochmans , Vincent Dubée , Mehran Monchi , Sylvain Diamantis
DOI: 10.1155/2020/2093468
关键词:
摘要: Introduction Treatment of Haemophilus influenzae (Hi) pneumonia is on concern because resistance to amoxicillin largely diffused. This study describes the evolution and amoxicillin/clavulanic acid (AMC) in Hi isolates characteristics patients with severe pneumonia. Methods A monocentric retrospective observational including from 2008 2017 hospitalized ICU. Evolution AMC susceptibility was showed. Characteristics were compared Streptococcus pneumoniae (Sp) pneumonia, as reference. Risk factors for investigated. Results Overall, 113 132 Sp included. The percentages among strains decreased over years (from 10% 2008-2009 0% 2016-2017) while remained stable at 20%. Also, resistant 25% 3%). Patients experienced higher prevalence bronchitis (18% vs. 8%, p=0.02, chronic obstructive pulmonary disease (43% 30% p=0.03), HAP 7%, p=0.01, ventilator-associated (27% 17%, p=0.04, longer duration mechanical ventilation (8 days 6 days, p=0.04) than had more frequently local complications (17% p=0.03). De-escalation antibiotics frequent (67% 53%, No risk associated Conclusions Amoxicillin time, but no detected. extremely low, suggesting that could be used empiric treatment well other molecules, namely, cephalosporins. comorbidities diseases
hindawi.com参考文章(16)
I.M. Gould, The epidemiology of antibiotic resistance International Journal of Antimicrobial Agents. ,vol. 32, pp. S2- S9 ,(2008) , 10.1016/J.IJANTIMICAG.2008.06.016
Angel Vila-Corcoles, Ferran Bejarano-Romero, Elisabeth Salsench, Olga Ochoa-Gondar, Cinta de Diego, Frederic Gomez-Bertomeu, Xavier Raga-Luria, Xavier Cliville-Guasch, Victoria Arija, Drug-resistance in Streptococcus pneumoniae isolates among Spanish middle aged and older adults with community-acquired pneumonia BMC Infectious Diseases. ,vol. 9, pp. 36- 36 ,(2009) , 10.1186/1471-2334-9-36
A. Dalhoff, Resistance surveillance studies: a multifaceted problem--the fluoroquinolone example. Infection. ,vol. 40, pp. 239- 262 ,(2012) , 10.1007/S15010-012-0257-2
E. Weiss, J.-R. Zahar, P. Lesprit, E. Ruppe, M. Leone, J. Chastre, J.-C. Lucet, C. Paugam-Burtz, C. Brun-Buisson, J.-F. Timsit, C. Brun-Buisson, F. Bruneel, J. Chastre, S. Lasocki, M. Leone, P. Montravers, S. Nseir, C. Paugam-Burtz, S. Pease, J.-F. Timsit, E. Weiss, M. Wolff, S. Alfandari, B. Fantin, B. Gachot, P. Lesprit, J.-C. Lucet, G. Potel, C. Pulcini, C. Rabaud, P. Tattevin, L. Armand-Lefevre, J.-D. Cavallo, V. Jarlier, O. Joint-Lambert, J. Robert, E. Ruppé, P.-L. Woerther, Elaboration of a consensual definition of de-escalation allowing a ranking of β-lactams Clinical Microbiology and Infection. ,vol. 21, pp. 649- ,(2015) , 10.1016/J.CMI.2015.03.013
R. Leclercq, R. Cantón, D.F.J. Brown, C.G. Giske, P. Heisig, A.P. MacGowan, J.W. Mouton, P. Nordmann, A.C. Rodloff, G.M. Rossolini, C.-J. Soussy, M. Steinbakk, T.G. Winstanley, G. Kahlmeter, EUCAST expert rules in antimicrobial susceptibility testing Clinical Microbiology and Infection. ,vol. 19, pp. 141- 160 ,(2013) , 10.1111/J.1469-0691.2011.03703.X
T Welte, A Torres, D Nathwani, Clinical and economic burden of community-acquired pneumonia among adults in Europe Thorax. ,vol. 67, pp. 71- 79 ,(2012) , 10.1136/THX.2009.129502
Christina Forstner, Gernot Rohde, Jan Rupp, Hartwig Schuette, Sebastian R. Ott, Stefan Hagel, Nicole Harrison, Florian Thalhammer, Heike von Baum, Norbert Suttorp, Tobias Welte, Mathias W. Pletz, S. Krüger, D. Frechen, W. Knüppel, I. Armari, D. Stolz, N. Suttorp, H. Schütte, P. Creutz, T. Bauer, J. Hecht, W. Pankow, A. Lies, D. Thiemig, B. Hauptmeier, D. Wehde, M. Suermann, S. Ewig, M. Prediger, G. Zernia, T. Welte, J. Rademacher, G. Barten, M. Abrahamczik, J. Naim, W. Kröner, T. Illig, N. Klopp, C. Kroegel, M. Pletz, R. Bals, K. Dalhoff, S. Schütz, R. Hörster, G. Rohde, W. Petermann, H. Buschmann, R. Kröning, Y. Aydin, T. Schaberg, I. Hering, R. Marre, C. Schumann, H. von Baum, T. Illmann, M. Wallner, O. Burghuber, G. Rainer, Community-acquired Haemophilus influenzae pneumonia – New insights from the CAPNETZ study Journal of Infection. ,vol. 72, pp. 554- 563 ,(2016) , 10.1016/J.JINF.2016.02.010
Hayato Yamana, Hiroki Matsui, Takashi Tagami, Junko Hirashima, Kiyohide Fushimi, Hideo Yasunaga, De-escalation versus continuation of empirical antimicrobial therapy in community-acquired pneumonia Journal of Infection. ,vol. 73, pp. 314- 325 ,(2016) , 10.1016/J.JINF.2016.07.001
Jordi Carratalà, Ali A. El Solh, Santiago Ewig, Paul D. Fey, Thomas M. File, Marcos I. Restrepo, Jason A. Roberts, Grant W. Waterer, Peggy Cruse, Shandra L. Knight, Jan L. Brozek, Andre C. Kalil, Mark L. Metersky, Michael Klompas, John Muscedere, Daniel A. Sweeney, Lucy B. Palmer, Lena M. Napolitano, Naomi P. O'Grady, John G. Bartlett, Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society Clinical Infectious Diseases. ,vol. 63, pp. 575- 582 ,(2016) , 10.1093/CID/CIW353
Diego Viasus, Antonella F. Simonetti, Carolina Garcia-Vidal, Jordi Niubó, Jordi Dorca, Jordi Carratalà, Impact of antibiotic de-escalation on clinical outcomes in community-acquired pneumococcal pneumonia. Journal of Antimicrobial Chemotherapy. ,vol. 72, pp. 547- 553 ,(2017) , 10.1093/JAC/DKW441